Akwukwo Mulberry DNJ mulberry akwukwo weputara ihe eji eme ahu ike

Ozi ngwaahịa

Akwụkwọ Mulberry DNJ bụ alkaloid eke, nke aha Chinese bụ 1-deoxynojirimycin.Ọ bụ ihe na-eme ka glucose metabolizing enzyme (dịka ọmụmaatụ α- Glycosidase) inhibitor nwere ike gbuo oge mmebi nke polysaccharide, belata uru kacha elu nke glucose ọbara postprandial ma mee ka glucose ọbara na-ebu ọnụ guzosie ike;Ọ bụ nke "ihe mgbochi" n'etiti ihe anọ na-achịkwa shuga nke alfa.
1. Mmetụta nke mulberry akwukwo DNJ
1. Ụzọ atọ iji belata glucose ọbara
Dị ka onye na-egbochi glucose metabolizing enzymes (dịka ọmụmaatụ, α- Glucosidase, hexokinase, glucuronidase na glycogen phosphatase, wdg), DNJ nwere ike igbu oge nbibi nke polysaccharide, belata uru kacha elu nke glucose ọbara postprandial ma kwụsie ike glucose ọbara na-ebu ọnụ.Na mgbakwunye, DNJ nwere mmetụta nke mmetụta insulin iji meziwanye nguzogide insulin.
2. Belata shuga ọbara postprandial.
α- Glucosidase na-ekesa nke ọma n'ime eriri afọ mmadụ ma na-arụ ọrụ dị mkpa na mwepu nke carbohydrates.Ha na-ahụ maka ire ere nke oligosaccharides dị ka oligosaccharides na nri n'ime monosaccharides, dị ka glucose.Glucose ndị a na-abanye n'ime ahụ site na mgbidi eriri afọ, na-eme ka mmụba dị elu nke mkpokọta glucose n'ọbara.DNJ bụ ihe okike ma dị ike α- Glucosidase inhibitors nke na-ejikọta asọmpi na obere eriri afọ α- Njikọ nke glucosidase dị elu karịa nke oligosaccharides dị ka sucrose na maltose α- Glucosidase nwere njikọ siri ike ma na-ebelata oligosaccharides na α- Enwere ike nke glucosidase. , nke mere na iji gbochie ire ere nke fructose n'ime glucose, na nnukwu shuga agaghị etinye ya na eriri afọ.N'ihi mmetụta nke DNJ, obere glucose na-abanye n'ọbara, yabụ glucose ọbara kwesịrị idowe ọkwa dị mma.
3. Glucose ọbara na-ebu ọnụ kwụsie ike.
DNJ nwere ọrụ mgbochi nke glycogen phosphorylase, nke nwere ike belata mmebi nke imeju glycogen n'ime glucose, iji mee ka glucose ọbara na-ebu ọnụ kwụsie ike.A na-echekwa glucose "oke" dị n'ahụ mmadụ n'ime imeju n'ụdị glycogen.Enwere ike ịgbaji glycogen ka ọ bụrụ glucose n'okpuru ọrụ glycogen phosphorylase wee hapụ ya n'ọbara iji gboo mkpa akwara na ọrụ akụkụ ndị ọzọ.Glycogen bụ otu n'ime isi mmalite ike maka mmega ahụ.Site na ngbanwe dị n'etiti glycogen na glucose, glucose ọbara nke ndị nkịtị na-enwe nguzozi siri ike.N'ime ndị ọrịa nwere ọrịa shuga, n'ihi arụ ọrụ nke metabolism metabolism, oke glycogen ga-agbaji banye glucose, na-ebute mmụba na-adịghị mma nke glucose ọbara na-ebu ọnụ.DNJ nwere ike igbochi ọrụ nke glycogen phosphorylase ma gbochie mmụba nke glucose ọbara kpatara oke glycogen ire ere n'ime glucose, iji mee ka glucose ọbara na-ebu ọnụ kwụsie ike.
4. Melite nguzogide insulin.
DNJ nwere ike imeziwanye ihe mgbaàmà nke nguzogide insulin site na mezie metabolism lipid, na-ebelata mmepụta glucose na mmetụta insulin.Nguzogide insulin na-ezo aka n'ihe dị iche iche (gụnyere ihe mkpụrụ ndụ ihe nketa na oke ibu), nke na-ebelata arụmọrụ nke insulin na-akwalite nnabata glucose na itinye n'ọrụ, na ahụ na-akwụghachikwa insulin buru ibu.Nguzogide insulin na-emepụta hyperinsulinemia iji nọgide na-enwe nkwụsi ike nke glucose ọbara n'ime ahụ.Ọ bụrụ na ahụ mmadụ nọ n'ọnọdụ mgbochi insulin ogologo oge, ọ ga-abawanye ibu nke pancreas.Ọ nwere ike ime ka pancreas zobe ọdịda nke ọrụ insulin wee malite ghọọ ọrịa shuga.DNJ nwere ike imeziwanye ihe mgbaàmà nke nguzogide insulin site n'ịkwado ọkwa glucose ọbara dị mma, na-edozi metabolism lipid na ịba ụba nke insulin.
2. Ngwa ubi nke mulberry akwukwo DNJ
Akwukwo akwukwo mulberry weputara akwukwo mulberry DNJ ka edeputara dika ihe inyeaka hypoglycemic ma na-eji ya na nri ahu ike.

Ngwa ngwaahịa

NKỌWAPỤTA ỤLỌ ỌRỤ
Aha ngwaahịa	Akwụkwọ Mulberry DNJ
CAS	19130-96-2
Usoro ọgwụ	C6H13NO4
Brand	Hande
Monye na-emepụta ihe	YUnnan Hande Bio-Tech Co., Ltd.
Cọntry	Kunming,China
Eguzobere	1993
BOzi ASIC
Ụdị okwu	(2r,3r,4r,5s) -2-hydroxymethyl-3,4,5-trihydroxypiperidine;5-piperidinetriol, 2- (hydroxymethyl) -, (2r- (2alpha, 3beta, 4alpha, 5beta)) -4; bay-h5595; moranolin; moranoline; (+)-1-DEOXYNOJIRIMYCIN;1-DEOXYNOJIRIMYCIN;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
Nhazi
Ibu	N/A
HKoodu S	N/A
OgoSpecification	Nkọwapụta ụlọ ọrụ
Cakwụkwọ ikike	N/A
Nyocha	Haziri dịka mkpa ndị ahịa siri dị
Ọdịdị	Ọcha ntụ ntụ
Ụzọ nke mmịpụta	Ewepụtara na mulberry epupụta na mgbọrọgwụ ogbugbo
Ike kwa afọ	Haziri dịka mkpa ndị ahịa siri dị
ngwugwu	Haziri dịka mkpa ndị ahịa siri dị
Usoro ule	HPLC
Logistics	Otutunjems
PokwuTokwu	T/T, D/P, D/A
Oebe ahụ	Nabata nyocha ndị ahịa mgbe niile;Nyere ndị ahịa aka na ndebanye aha nhazi.

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