Ozi ngwaahịa
Artemisinin bụ ọgwụ nwere mmetụta kachasị mma na ọgwụgwọ ịba.Ọ bụ sesquiterpene lactone nwere peroxide otu ewepụtara na Artemisia annua.Ọ nwere njirimara nke arụmọrụ dị elu, mmetụta ngwa ngwa, ikpochapụ okpomọkụ na iwelata okpomọkụ okpomọkụ, ibelata okpomọkụ adịghị ike, igbu protozoa na obere nsị.Ka ọ dị ugbu a, ịdị irè nke ọgwụgwọ artemisinin dabeere na nkwonkwo (ACT) maka ọgwụgwọ ịba eruola karịa 90% n'ụwa nile.A na-eji ya agwọ ọrịa ịba n'ụwa niile.
1. Ọrụ
1. Mgbochi ịba
ịba (nke a na-akpọkarị oyi oyi na ọrịa ahụ ọkụ) bụ ọrịa na-efe efe nke ụmụ ahụhụ na-ebute.Ọ bụ ọrịa na-efe efe na-ebute site na aru mmadụ nke Plasmodium butere.Ọ nwere ike ịpụta hepatosplenomegaly na anaemia mgbe mwakpo ugboro ugboro ruo ogologo oge.Artemisinin enyela aka na ọgwụgwọ ịba ruo n'ókè ụfọdụ.Njikọ peroxide dị na nhazi nke artemisinin na-agbaze ma bụrụ otu dị mkpa maka iguzogide ịba.Usoro a na-eme bụ na otu nnwere onwe nke artemisinin mepụtara na vivo na-ejikọta protein Plasmodium falciparum ma gbanwee nhazi cell membrane nke Plasmodium falciparum.Mgbe radicals free jikọtara ya na protein Plasmodium, akpụkpọ anụ bilayer nke mitochondria ga-aza ma gbawaa, ma mesịa daa, na-akpata mbibi nke usoro cell na ọrụ nke Plasmodium, na chromatin na nucleus ga-emetụtakwa ụfọdụ. oke.
2. Antitumor
Akpụ akpụ bụ nke mbụ na-egbu ahụike mmadụ.Ọ bụrụ na agwọghị ya n'oge, ọ ga-etinye nchekwa ndụ n'ihe egwu.Nnwale in vitro gosiri na ụfọdụ ọgwụ artemisinin nwere ike ịkpata apoptosis nke ọtụtụ ụdị mkpụrụ ndụ kansa, dị ka mkpụrụ ndụ hepatoma, mkpụrụ ndụ kansa ara, mkpụrụ ndụ kansa cervical na ihe ndị ọzọ, ma gbochie uto mkpụrụ ndụ kansa.Achọpụtara na artemisinin nwere ike ịhazi okwu nke cyclin n'ime mkpụrụ ndụ tumo, kwalite mmetụta nke CKI ma na-eduga na njide nke usoro mkpụrụ ndụ tumo;Ma ọ bụ na-eduga na apoptosis ma na-egbochi ụbụrụ angiogenesis iji guzogide ihe omume na mmepe nke etuto ahụ.A na-eji Artemisinin na-agwọ ọrịa leukemia site n'ime ihe na-eme na akpụkpọ ahụ nke sel leukemia, na-amụba permeability nke akpụkpọ ahụ ma na-agbanwe nrụgide osmotic, na-ebute mmụba nke calcium n'ime sel, iji mee ka calpain rụọ ọrụ, na-eme ka akpụkpọ ahụ sel ya zaa. na mgbawa, mee ngwa ngwa ntọhapụ nke ihe apoptotic ma na-abawanye ọsọ nke apoptosis.
3. Ọgwụgwọ ọbara mgbali elu pulmonary
ọbara mgbali elu Pulmonary (PAH) bụ ọnọdụ pathophysiological nke ejiri ngbanwe akwara akpa ume na ịrị elu nke akwara pulmonary ruo n'ókè ụfọdụ.Ọ nwere ike ịbụ mgbagwoju anya ma ọ bụ ọrịa syndrome.A na-eji Artemisinin na-agwọ ọbara mgbali elu nke akpa ume: ọ nwere ike ibelata ọbara mgbali elu ma melite mgbaàmà na ndị ọrịa nwere PAH site na ime ka arịa ọbara dị jụụ.Zaiman et al.Achọpụtara na artemisinin nwere mmetụta mgbochi mkpali.Artemisinin na ihe ndị bụ isi ya nwere ike igbochi ihe dị iche iche nke mkpali, ma nwee ike igbochi mmepụta nke nitric oxide site na ndị mgbasa ozi na-ekpo ọkụ;Artemisinin nwere mmetụta immunomodulatory;Feng Yibai na ndị ọzọ chọpụtara na artemisinin nwere ike igbochi mgbasa nke sel endothelial vaskụla na sel anụ ahụ dị nro, wee rụọ ọrụ dị mkpa na ọgwụgwọ PAH;Artemisinin nwere ike igbochi ọrụ nke matrix metalloproteinases, si otú ahụ na-egbochi imezigharị akwara pulmonary;Artemisinin nwere ike igbochi okwu nke cytokines metụtara PAH ma kwalite mmetụta mgbochi vaskụla nke artemisinin.
4. Usoro mgbochi ọrịa
Achọpụtara na usoro onunu ogwu nke artemisinin na ihe ndị sitere na ya nwere ike igbochi T lymphocyte mitogen ma mee ka mmụba nke lymphocytes splin òké na-enweghị cytotoxicity.Nchọpụta a nwere ezigbo ntụaka maka ọgwụgwọ T lymphocyte mediated autoimmune ọrịa.Artemisia annua glass mmanya nwere ike welie mgbochi na-enweghị isi ma melite mkpokọta mmeju nke serum òké.Dihydroartemisinin nwere ike igbochi mgbasa nke B lymphocytes ozugbo, belata nzuzo nke autoantibodies site na B lymphocytes, belata nzaghachi anụ ahụ nke anụrị, na-egbochi mgbochi ihu ọchị ma belata nguzobe nke mgbochi.
5. Antifungal
Mmetụta antifungal nke artemisinin na-emekwa ka artemisinin gosipụta ụfọdụ ọrụ nje.Nnyocha ahụ gosipụtara na ntụ ntụ fọdụrụ na mmiri decoction nke artemisinin nwere mmetụta antibacterial siri ike na anthrax, Staphylococcus epidermidis, catarrhalis na diphtheria, ma nweekwa mmetụta antibacterial na ụkwara nta, Pseudomonas aeruginosa, Staphylococcus aureus na dysentery bacilli.
2. Ogige ngwa
A na-eji Artemisia annua dị ka ọgwụ mgbochi ịba.Ngwa ụlọ ọgwụ ya egosila na artemisinin na ihe ndị sitere na ya nwere mmetụta pụrụ iche na Plasmodium falciparum na Plasmodium falciparum, ọkachasị Artemisia annua a, nke nwere mmetụta siri ike karịa ọgwụ artemisinin ndị ọzọ na-egbu clones intracellular nke Plasmodium falciparum.
Ngwa ngwaahịa
| NKỌWAPỤTA ỤLỌ ỌRỤ | |
| Aha ngwaahịa | Artemisinin |
| CAS | 63968-64-9 |
| Usoro ọgwụ | C15H22O5 |
| Brand | Hande |
| Monye na-emepụta ihe | YUnnan Hande Bio-Tech Co., Ltd. |
| Cọntry | Kunming,China |
| Eguzobere | 1993 |
| BOzi ASIC | |
| Ụdị okwu | 3,12-epoxy-12h-pyranol (4,3-j) -1,2-benzodioxepin-10 (3h) - otu, octahydro-3,6,9-tri;artemisiaannual., wepụ;huanghuahaosu;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(;qinghausau;qinghausu; QHS; ARTEMISININ 99% |
| Nhazi |  |
| Ibu | 282.34 |
| HKoodu S | N/A |
| OgoSpecification | Nkọwapụta ụlọ ọrụ |
| Cakwụkwọ ikike | N/A |
| Nyocha | Haziri dịka mkpa ndị ahịa siri dị |
| Ọdịdị | Crystal acicular na-enweghị agba |
| Ụzọ nke mmịpụta | Artemisia afọ |
| Ike kwa afọ | Haziri dịka mkpa ndị ahịa siri dị |
| ngwugwu | Haziri dịka mkpa ndị ahịa siri dị |
| Usoro ule | N/A |
| Logistics | Otutunjems |
| PokwuTokwu | T/T, D/P, D/A |
| Oebe ahụ | Nabata nyocha ndị ahịa mgbe niile;Nyere ndị ahịa aka na ndebanye aha nhazi. |
Nkwupụta ngwaahịa Hande
1.All ngwaahịa ndị ụlọ ọrụ na-ere bụ ihe eji emecha ihe.A na-ezubere ngwaahịa ndị a maka ndị nrụpụta nwere ntozu mmepụta, na akụrụngwa abụghị ngwaahịa ikpeazụ.
2.Ihe nwere ike ịrụ ọrụ na ngwa ndị na-etinye aka na mmeghe sitere na akwụkwọ ndị e bipụtara.Ndị mmadụ n'otu n'otu anaghị akwado iji ya eme ihe ozugbo, a jụrụ ịzụrụ onye ọ bụla.
3. Foto na ozi ngwaahịa dị na webụsaịtị a bụ naanị maka ntụnye aka, na ngwaahịa ahụ ga-emeri.
