Paclitaxel, ngwaahịa sitere n'okike nke fir na-acha uhie uhie, na-egbochi mitosis cell tumor site na ime ihe na protein microtubule.Ọ bụ ihe nnọchianya nke klas paclitaxel na ọ bụ ọgwụ kemịkalụ mbụ sitere na ihe ọkụkụ sitere n'okike iji nweta nkwado FDA maka ọgwụgwọ ọrịa cancer dị iche iche, gụnyere ovarian, ara, ngụgụ, sarcoma Kaposi, cervical na pancreatic cancer.N'afọ adịbeghị anya,paclitaxelenweela ewu ewu maka iji ya na ngwaọrụ ahụike.Ka anyị leba anya na ya n’isiokwu na-esonụ.
Ojiji nkepaclitaxelna ngwaọrụ ahụike
Paclitaxel, site na polymerization n'otu oge na α (α-tubulin) na β (β-tubulin) nke microtubulin, na-eme ka ọnụ ọgụgụ buru ibu nke microtubules polymerize na-adịghị mma, na-ebute mgbanwe nke ọnọdụ skeletal nha nha nke mkpụrụ ndụ na nkwụsị nke ọrụ nkịtị. na-eme ka mmepe sel kwụsị na G0 / G1 na G1 na GM, na cell mitosis ka a ga-egbochi ya na oge mitotic, n'ikpeazụ na-enweta nkwụsị nke vascular smooth muscle division, proliferation Nsonaazụ bụ igbochi nkewa na mmụba nke vaskụla ahụ dị nro. ma gbochie restenosis ime.
1. Paclitaxelọgwụ stent
Drug-eluting stent (DES) bụ stent nke na-eji igwe stent efu na-ebu (ebu) ọgwụ mgbochi endothelial proliferation, nke a na-ewepụta site na elution mpaghara n'ime arịa ahụ iji gbochie mgbasa nke endothelial nke ọma iji gbochie restenosis n'ime ahụ. stent.Iji ọgwụ eme ihe nke ọma na-eme ka stent na-eme ka ọ ghara ịdị irè belata mmetụta nke restenosis na ntinye aka ọzọ, mana o belataghị ọnụ ọgụgụ nke ọrịa na ọnwụ.Enweghị ọdịiche dị ịrịba ama na ihe omume nke njedebe ụlọ ọgwụ n'etiti stent-eluting ọgwụ, na ụfọdụ njedebe nke abụọ na-erite uru.Ihe mgbochi ọgwụ na-agụnye stent efu mere nke igwe anaghị agba nchara ma ọ bụ cobalt-chromium nke ejiri ndị na-ebu ọgwụ antiproliferative kpuchie ya na mkpuchi nnyefe ọgwụ polymeric gụnyere teknụzụ mkpuchi mkpuchi na-adịgide adịgide, biodegradable na polymer na-enweghị polymer, ma nwee ọgwụ gụnyere limoxylates na paclitaxel.Ugbu a, a na-ejikarị stent ọgwụ paclitaxel na-agwọ ọrịa dị iche iche nke akwara obi, intracranial, carotid, renal na femoral arteries.
2. Balloons ejiri ọgwụ Paclitaxel kpuchie
Balloon mkpuchi ọgwụ (DCB), dị ka usoro ntinye aka ọhụrụ na tozuru oke, egosipụtara n'ọtụtụ nnwale ụlọ ọgwụ maka ịdị irè ya na nchekwa na ISR, ọnya intracoronary stenosis ọnya, obere ọnya ụgbọ mmiri, ọnya bifurcation, wdg.
Mara: Enwere ike ịrụ ọrụ na ngwa a kọwara n'isiokwu a sitere na akwụkwọ ebipụtara.
Ọgụgụ agbatịkwuru:Yunnan Hande Biotechnology Co., Ltd nọ na-elekwasị anya na mmepụta nke paclitaxel kemgbe afọ 28.Ọ bụ ụlọ ọrụ izizi nọọrọ onwe ya n'ụwa nke paclitaxel ọgwụ anticancer sitere na osisi nke US FDA, European EDQM, Australian TGA, China CFDA, India, Japan na ụlọ ọrụ nchịkwa mba ndị ọzọ kwadoro.ụlọ ọrụ.Ọ bụrụ na ị chọrọ ịzụPaclitaxel API, biko kpọtụrụ anyị online.
Oge nzipu: Ọkt-09-2022