Usoro mgbochi tumor pụrụ iche nke Paclitaxel

Paclitaxel bụ ọgwụ magburu onwe ya na-egbochi ọrịa cancer nke a chọtara ugbu a. A na-ejikarị ya eme ihe na ọgwụgwọ ụlọ ọgwụ nke ọrịa cancer ovarian, ọrịa ara ara, ọrịa cancer akpa ume, isi na olu, cancer esophageal, cancer gastric na sarcoma anụ ahụ dị nro.Paclitaxeladọtala mmasị dị ukwuu site n'aka ndị ọkà mmụta sayensị n'ihi usoro kemịkalụ ya dị mgbagwoju anya na nke ọhụrụ, usoro ihe omume pụrụ iche nke usoro ihe omume, ọrụ anticancer a pụrụ ịdabere na ya, na ụkọ ihe onwunwe siri ike. Dị ka ọnụ ọgụgụ si kwuo, ihe karịrị 30 top laboratories gburugburu ụwa etinyewo aka na nyocha nke Total. njikọ nke paclitaxel, na asọmpi ahụ dị oke egwu, nke ghọrọ ihe na-elekwasị anya na kemịkalụ sịntetik organic na njedebe narị afọ nke 20.

Usoro mgbochi tumor pụrụ iche nke paclitaxel

Paclitaxel nwere ike ime ka Tubulin na Tubulin dimer nke mebere microtubules tụfuo nha nhata Dynamic, kpalite ma kwalite Tubulin polymerization, mgbakọ microtubule, na igbochi depolymerization, iji mee ka microtubules kwụsie ike na igbochi mitosis nke mkpụrụ ndụ kansa na ịkpalite apoptosis, si otú ahụ na-egbochi nke ọma ịba ụba nke ọrịa cancer. sel na ịrụ ọrụ mgbochi ọrịa kansa.

N'ezie, Tubulin, nke nwere njikọ chiri anya na cell Mitosis, dị ihe fọrọ nke nta ka ọ bụrụ n'ụwa nile na sel eukaryotic nile. Ha nwere ike polymerize n'ime microtubules reversibly. Nkewa chromosome chọrọ enyemaka nke microtubules ndị a. Mgbe Mitosis gasịrị, a na-atụgharị microtubules ndị a ọzọ na Tubulin. disintegration nke hama dị ka microtubules nwere ike preferentially igbu sel ndị na-adịghị mma nkewa.Ụfọdụ mkpa mgbochi ọrịa cancer, dị ka colchicine,Vinblastine,Vincristine,egwu ihe mgbochi tumor ọrụ site na igbochi Tubulin si re polymerization.

N'adịghị ka mgbochi Mitosis na ọgwụ mgbochi tumor,paclitaxelbụ ọgwụ mbụ a chọtara nke nwere ike ịmekọrịta na Tubulin polymer, ya bụ, ọ na-arụ ọrụ site na ijikọta ya na microtubules iji mee ka ha kwụsie ike. nchọpụta adọtala ọtụtụ ndị ọkà mmụta ihe ndị dị ndụ ijipaclitaxeldị ka ngwá ọrụ nyocha na biomedicine, na-enyocha mpaghara ọrụ cell amabeghị na ịchọpụta ụzọ ọhụrụ maka ọgwụ mgbochi ọrịa cancer.

Nkọwa: Enwere ike ịrụ ọrụ na ngwa ndị a kpọtụrụ aha n'isiokwu a niile sitere na akwụkwọ ọha nwere.

Yunnan Hande Bio-tech na-elekwasị anya na mmepụta nke paclitaxel maka afọ 28.Ọ bụ ụlọ ọrụ mmepụta ihe kwụụrụ onwe ya nke akụrụngwa paclitaxel, nke ụlọ ọrụ nchịkwa mba dị ka FDA na United States kwadoro, EDQM na Europe, TGA na Australia, CFDA na China, India na Japan.Yunnan Handepaclitaxeldị na ngwaahịa ma na-ere ya ozugbo site n'aka ndị nrụpụta.Nnọọ ịjụ ajụjụ.