A na-ewere ọgwụ Paclitaxel dị ka ọgwụgwọ mbụ maka ọrịa ara ara, a na-ejikwa ya n'ọtụtụ ebe maka ọrịa cancer ovarian, ọrịa cancer akpa ume, ụbụrụ isi na olu, ọrịa cancer esophageal, cancer gastric na sarcoma anụ ahụ dị nro.N'ime afọ ndị na-adịbeghị anya, site na nyocha na-aga n'ihu na ọgwụ paclitaxel na-aga n'ihu na-emeziwanye usoro nhazi ahụ, ọgwụ ndị a na-agụnye ugbu a na-agụnye paclitaxel injection, docetaxel (docetaxel), liposomal paclitaxel na albumin-bound paclitaxel.Yabụ kedu ihe dị iche n'etiti ọgwụ paclitaxel ndị a, ka anyị mụtakwuo banyere ha n'okpuru.
I. Ọdịiche dị na ọrụ ndị bụ isi
1. Paclitaxel injection: A na-egosi ya maka usoro ọgwụgwọ mbụ na usoro ọgwụgwọ nke ọrịa cancer ovarian na-aga n'ihu, ọgwụgwọ adjuvant nke lymph node-positive cancer cancer mgbe usoro ọgwụgwọ nke adriamycin nwere ngwakọta chemotherapy, ọrịa ara ara na ọrịa cancer metastatic nke Nchikota chemotherapy dara ada ma ọ bụ laghachi azụ n'ime ọnwa 6 nke adjuvant chemotherapy, ọgwụgwọ nke mbụ nke ọrịa kansa akpa ume na-abụghị obere cell, na ọgwụgwọ nke abụọ nke ọrịa AIDS ọrịa carcinosarcoma metụtara.
2. Docetaxel: Maka ọgwụgwọ ọrịa kansa ara ma ọ bụ metastatic nke dara tupu chemotherapy;maka ọgwụgwọ nke elu ma ọ bụ metastatic ọrịa cancer akpa ume na-abụghị obere cell nke dara na chemotherapy dabeere na cisplatin.Ọ dịkwa irè maka ọrịa kansa afọ na ọrịa prostate.
3. Liposomal paclitaxel: Enwere ike iji ya dị ka chemotherapy nke mbụ maka ọrịa cancer ovarian na chemotherapy nke mbụ maka ọgwụgwọ ọrịa cancer metastatic ovarian, a pụkwara iji ya na cisplatin.A pụkwara iji ya mee ihe na-esochi ndị ọrịa cancer ara bụ ndị e jirila ọgwụ chemotherapy nke nwere adriamycin mee ihe ma ọ bụ maka ọgwụgwọ ndị ọrịa nwere nlọghachi azụ.Enwere ike iji ya na cisplatin dị ka chemotherapy nke mbụ maka ndị ọrịa nwere ọrịa cancer akpa ume na-abụghị obere cell bụ ndị a na-apụghị ịgwọta na ịwa ahụ ma ọ bụ redio.
4. Albumin-bound paclitaxel: egosiputara maka ọgwụgwọ ọrịa kansa metastatic nke dara nchikota chemotherapy ma ọ bụ maka ọrịa ara ara nke maliteghachiri n'ime ọnwa 6 ka adjuvant chemotherapy gasịrị.Ọ gwụla ma enwere mgbochi ụlọ ọgwụ, chemotherapy gara aga kwesịrị ịgụnye ọgwụ anthracycline anticancer.
II.Ọdịiche dị na nchekwa ọgwụ
1. Paclitaxel: mmiri na-adịghị mma solubility.N'ozuzu, ntụtụ ahụ ga-agbakwunye mmanụ castor nke na-anọchi anya polyoxyethylene na ethanol iji meziwanye solubility nke paclitaxel na mmiri, ma a na-ahapụ histamine mgbe mmanụ castor dochie polyoxyethylene na-emebi na vivo, nke nwere ike ibute mmeghachi ahụ nfụkasị siri ike ma nwee ike ime ka ọ dịkwuo njọ. neurotoxicity nke paclitaxel, ma nwee ike imetụta mgbasa nke mkpụrụ ndụ ọgwụ na anụ ahụ ma na-emetụta mmetụta mgbochi tumor.
2. Docetaxel: mmiri solubility dị ala, ọ dịkwa mkpa ka a na-edozi ya site n'ịgbakwunye polysorbate 80 na ethanol anhydrous, nke abụọ nwere ike ime ka mmeghachi omume na-adịghị mma ma nwee ike ịkpata mmeghachi omume nfụkasị na hemolytic.
3. Liposomal paclitaxel: a na-etinye ọgwụ ahụ na lipid-like bilayers iji mepụta obere vesicles, na ọgwụ ahụ na-ekpuchi ya na mkpụrụ ndụ liposomal na-enweghị mmanụ castor na-anọchi anya polyoxyethylene na ethanol anhydrous, nke na-akpata mmeghachi ahụ nfụkasị ahụ.Otú ọ dị, ọmụmụ egosiwo na ọgwụ paclitaxel n'onwe ya nwekwara ike ime ka mmeghachi omume hypersensitivity, ma na ọnụ ọgụgụ dị ala ma e jiri ya tụnyere ọgwụ ogwu paclitaxel.Ka ọ dị ugbu a, paclitaxel liposomes ka chọrọ ọgwụgwọ pretreatment nrịanrịa tupu ejiri ya.
4. Albumin-bound paclitaxel: Onye na-ahụ maka paclitaxel albumin lyophilized ọhụrụ na-eji albumin mmadụ dị ka onye na-ebu ọgwụ na stabilizer, nke na-enweghị ihe mgbaze nke polyoxyethylene dochie mmanụ castor ma nwee ọdịnaya paclitaxel dị ntakịrị na paclitaxel liposomes, ma ọ nweghị. chọrọ pretreatment tupu ọgwụgwọ.
Rịba ama: A na-ewepụta arụmọrụ nwere ike na ngwa ekpuchiri na ngosi a site na akwụkwọ ndị e bipụtara.
Yunnan Hande Biotechnology Co., Ltd bụ ọkachamara na mmepụta nkepaclitaxel APImaka ihe karịrị afọ 20, ma bụrụ otu n'ime ndị na-emepụta onwe ya nke ụwa nke paclitaxel API, ọgwụ na-emepụta ihe ọkụkụ na-emepụta ọgwụ, nke US FDA kwadoro, European EDQM, Australian TGA, Chinese CFDA, India, Japan na ndị ọzọ na-ahụ maka nchịkwa obodo. .Hande nwere ike inye ọ bụghị naanị dị elupaclitaxel akụrụngwa, kamakwa ọrụ nkwalite teknụzụ metụtara usoro paclitaxel.Maka ozi ndị ọzọ, biko nweere onwe gị ịkpọtụrụ anyị na 18187887160.
Oge nzipu: Dec-08-2022