Paclitaxel bụ ihe sitere n'okike ewepụtara na osisi yew, nke nwere nnukwu ọrụ mgbochi tumor. Ebe ọ bụ na paclitaxel dịpụrụ adịpụ na ogbugbo nke Pacific yew na 1971, nyocha ya n'ihe gbasara ọgwụgwọ ọrịa kansa nwere nnukwu mmasị. inyocha omimi nke ọgwụgwọ mmetụta nkepaclitaxelna ụdị ọrịa cancer dị iche iche.
Ọdịdị na akụrụngwa nke paclitaxel
Paclitaxel bụ ngwakọta tetracyclic diterpenoid dị mgbagwoju anya nke nwere akụkụ atọ pụrụ iche, nke na-enye ndabere maka ọrụ mgbochi tumor ya. Usoro ihe omimi ya bụ C47H51NO14, ịdị arọ molecular bụ 807.9, ọ bụkwa ntụ ntụ ntụ ntụ na-acha odo odo na okpomọkụ.
Usoro mgbochi ọrịa cancer nkepaclitaxel
Usoro mgbochi ọrịa cancer nke paclitaxel na-emetụta ya na nkwụsị nke tubulin depolymerization na mmetụta ya na nkewa cell na mgbasawanye.Kpọmkwem, paclitaxel nwere ike ịkwalite microtubule polymerization ma gbochie microtubule depolymerization, si otú ahụ na-etinye aka na usoro nkịtị nke cell nkewa na mmụba, na-eduga. Na mgbakwunye, paclitaxel nwekwara ike ịkpata apoptosis cell ma gbochie tumor angiogenesis.
Mmetụta ọgwụgwọ nke paclitaxel na ụdị ọrịa cancer dị iche iche
1.Breast cancer: A na-amata mmetụta ọgwụgwọ nke paclitaxel na ọrịa ara ara. N'ime nnyocha nke ndị ọrịa ara ara 45, paclitaxel jikọtara ya na chemotherapy mere ka ụbụrụ tumor ebelata na 41% nke ndị ọrịa na ihe dị ndụ karịa ọnwa 20.
2. Ọrịa cancer akpa ume na-abụghị obere cell: Maka ọrịa cancer akpa ume na-abụghị obere cell, paclitaxel jikọtara ya na ọgwụ chemotherapy dabeere na platinum nwere ike ime ka ndụ ndị ọrịa dịkwuo mma. Nnyocha nke ndị ọrịa 36 nwere ọrịa cancer akpa ume na-abụghị obere cell gosiri na paclitaxel jikọtara ya na paclitaxel. ọgwụgwọ chemotherapy rụpụtara n'etiti ọnwa iri na abụọ.
3.Ovarian cancer: Na ọgwụgwọ nke 70 ọrịa cancer ovarian,paclitaxel jikọtara ya na platinum dabeere chemotherapy ọgwụ belata etuto ahụ na 76% nke ndị ọrịa, na afọ abụọ ndụ ọnụego ruru 38%.
4.Esophageal cancer: N'ọgwụgwọ nke ndị ọrịa 40 nwere ọrịa cancer esophageal, paclitaxel jikọtara ya na radiotherapy belata etuto ahụ na 85% nke ndị ọrịa, na ọnụ ọgụgụ nlanarị otu afọ ruru 70%.
5.Gastric cancer: Na ọgwụgwọ nke ọrịa kansa gastric, paclitaxel jikọtara na fluorouracil nwere ike imeziwanye ndụ nke ndị ọrịa. N'ime nnyocha nke ndị ọrịa 50 nwere ọrịa cancer gastric,paclitaxeljikọtara ya na ọgwụgwọ chemotherapy rụpụtara ndụ n'etiti ọnwa iri na ise.
6.Colorectal cancer: Na ọgwụgwọ nke 30 colorectal ọrịa cancer,paclitaxel jikọtara na oxaliplatin belatara etuto ahụ na 80% nke ndị ọrịa, na afọ abụọ ndụ ọnụego ruru 40%.
7. Ọrịa imeju: Ọ bụ ezie na mmetụta nke paclitaxel monotherapy na ọrịa cancer imeju dị oke, nchikota ọgwụ ndị ọzọ chemotherapy dị ka cisplatin na 5-fluorouracil nwere ike ime ka ndụ ndị ọrịa dịkwuo mma. Nnyocha nke ndị ọrịa 40 nwere ọrịa imeju na-egosi na paclitaxel jikọtara ọnụ. Site na ọgwụgwọ chemotherapy rụpụtara ndụ n'etiti ọnwa 9.
8.Kidney cancer: N'ọgwụgwọ ọrịa kansa akụrụ, paclitaxel jikọtara ya na ọgwụ immunomodulatory dị ka interferon-alpha nwere ike ime ka ndụ ndị ọrịa dịkwuo mma. Nnyocha e mere ndị ọrịa 50 nwere ọrịa kansa akụrụ gosiri na paclitaxel jikọtara ya na immunotherapy mere ka ndụ ndụ dịkwuo mma. Ọnwa iri abụọ na anọ.
9.Leukemia:N'ọgwụgwọ ọrịa leukemia myeloid ukwu,paclitaxel jikọtara ya na ọgwụ chemotherapy dị ka cytarabine nwere ike ime ka ndị ọrịa nweta oke mgbagha zuru oke. Nnyocha e mere ndị ọrịa 30 nwere nnukwu ọrịa leukemia myeloid na-egosi na paclitaxel jikọtara ya na chemotherapy mere ka ọ nweta nzaghachi zuru oke. n'ime 80% nke ndị ọrịa.
10, Lymphoma: Na ọgwụgwọ nke lymphoma na-abụghị Hodgkin, paclitaxel jikọtara ya na ọgwụ chemotherapy dị ka cyclophosphamide nwere ike ime ka ndị ọrịa nweta nzaghachi zuru oke zuru oke. Nnyocha nke ndị ọrịa 40 nwere lymphoma na-abụghị Hodgkin gosiri na paclitaxel jikọtara usoro ọgwụgwọ chemotherapy kpatara. na nzaghachi zuru oke na 85% nke ndị ọrịa.
Mmechi
Na nchịkọta, paclitaxel egosila ụfọdụ irè na ọgwụgwọ nke ụdị ọrịa cancer dị iche iche. Otú ọ dị, ọ dị mkpa iburu n'obi na ịdị irè nke ọgwụgwọ dịgasị iche iche maka ụdị ọrịa cancer ọ bụla ma na-achọkarị ya na ọgwụ ndị ọzọ. Tụkwasị na nke ahụ, n'ihi na ọ dị irè. mgbagwoju anya na ndịiche dị iche iche nke ọrịa cancer, atụmatụ ọgwụgwọ kwesịrị ịbụ ahaziri maka onye ọrịa ọ bụla. Ọmụmụ ihe ga-eme n'ọdịnihu ga-enyochakwu ikike nke paclitaxel na ọgwụgwọ ọrịa cancer ma kwalite ojiji ya.
Cheta na: Uru nwere ike na ngwa ewepụtara n'isiokwu a sitere na akwụkwọ ndị e bipụtara.
Oge nzipu: Nov-17-2023