Gosipụta njem dị mgbagwoju anya nke paclitaxel: site na nbipụta eke ruo na sịntetik nwere ike

Paclitaxel bụ ngwaahịa sitere n'okike nke ewepụtara site na ogbugbo nke osisi yew Pacific (Taxus pacifica) biosynthesis nke paclitaxel na-agụnye ụzọ biosynthetic siri ike, gụnyere ọtụtụ enzymes na intermediates. Nke a bụ nkọwa zuru ezu nke paclitaxel biosynthesis:

1.Malite ihe: biosynthesis nke paclitaxel na-amalite site na ihe mmalite sitere n'okike, na-emekarị site na epupụta ma ọ bụ ogbugbo nke osisi yew. Ihe mmalite ndị a nwere ogige ndị nne na nna nwere ike iji mee ka ihe ndị na-eme ka paclitaxel mee ihe.

2.Multi-enzyme catalysis: Biosynthesis nkepaclitaxelNa-achọ otutu enzymes iji kpata mmeghachi omume ahụ. Enzymes ndị a na-agbanwe ihe mmalite ka ọ bụrụ etiti etiti nke na-eji nwayọọ nwayọọ na-emepụta ihe ndị na-emepụta paclitaxel precursor molecules.

3.Synthesis nke intermediates: Intermediates bụ isi nzọụkwụ na njikọ nke paclitaxel. Ha na-agụnye polycyclic ogige na akụkụ yinye owuwu nke na-synthesized nwayọọ nwayọọ site na usoro nke enzyme-catalyzed mmeghachi omume.

4. Njikọ ikpeazụ nke paclitaxel: Mkpụrụ ndụ ndị na-ebute ụzọ maka njikọ nke paclitaxel na-eji nwayọọ nwayọọ na-ejikọta n'ime mkpụrụ ndụ paclitaxel n'ọtụtụ mmeghachi omume mmeghachi omume. Mmeghachi omume ndị a gụnyere njikọ polycyclic, acylation, deketone, na nzọụkwụ ndị ọzọ dị mkpa.

5.Extraction na ịdị ọcha: Mgbe njikọ nke paclitaxel gasịrị, a na-achọ ihe mmịpụta na nke dị ọcha iji kewaa paclitaxel dị ọcha na ngwakọta mmeghachi omume.

Ọ bụ ezie na eke biosynthetic ụzọ nkepaclitaxelA mụọla ya, n'ezie mmepụta nke paclitaxel na-anọgide na-esiri ike n'ihi na ọ na-achọ nhazi mgbagwoju anya na ọtụtụ nzọụkwụ na nnukwu ihe onwunwe. N'ihi ihe ịma aka ndị a, ndị ọkà mmụta sayensị enyochawokwa ụzọ sịntetik iji mepụta paclitaxel iji mee ka mkpụrụ na nnweta ya dịkwuo elu.Synthetic njikọ nke paclitaxel na-agụnyekarị ụzọ njikọ dị mfe karị iji belata mgbagwoju anya.

Cheta na: Uru nwere ike na ngwa ewepụtara n'isiokwu a sitere na akwụkwọ ndị e bipụtara.

Yunnan Hande Biotechnology Co., Ltd e lekwasịrị anya na mmepụta nke paclitaxel maka afọ 26, na ọ bụ onye na-emepụta onwe ya nke osisi na-ewepụta ọgwụ mgbochi ọrịa cancer paclitaxel API nke United States FDA kwadoro, European EDQM, Australia TGA, China CFDA. ,India,Japan na ndị ọzọ mba regulatory ụlọ ọrụ.Yunnan Hande paclitaxel, spot ọkọnọ, factory kpọmkwem ahịa, welcome toquest,18187887160(WhatsApp otu nọmba)