Paclitaxel bụ ọgwụ sitere n'okike nwere ọrụ mgbochi ọrịa kansa, nke a na-ejikarị agwọ ọrịa kansa dị iche iche.Paclitaxel APIna-anọgide na-emepe emepe. Isiokwu a ga-ewebata usoro mmepụta na nkà na ụzụ nke Paclitaxel API n'ụzọ zuru ezu.
Isi mmalite na mmịpụta nke Paclitaxel
Paclitaxel bụ tumadi ewepụtara si Taxus brevifolia, Taxus cuspidata, Taxus wallichiana na ndị ọzọ Taxus ụdị.Extraction ụzọ tumadi na-agụnye mgbaze mmịpụta, Ultrasonic mmịpụta, Microwave mmịpụta,etc.Ihe mgbaze mmịpụta bụ a na-eji usoro,ma o nwere nsogbu ndị dị ka ogologo mmịpụta oge. na nnukwu ihe mgbaze oriri. Ya mere, n'ime afọ ndị na-adịbeghị anya, ndị nchọpụta na-anọgide na-agbalị ụzọ ọhụrụ mmịpụta, dị ka enzyme hydrolysis, supercritical mmiri mmịpụta, wdg, iji melite mmịpụta arụmọrụ na ịdị ọcha.
II. Usoro mmepụta nke Paclitaxel
Usoro ịgba ụka maka mmepụta nke Paclitaxel
Na-adịbeghị anya, gbaa ụka ụzọ e nke ukwuu amụ maka mmepụta nke Paclitaxel.This usoro utilizes microbial gbaa ụka technology na-emepụta Paclitaxel site culturing na fermenting Taxus cell.The usoro nwere uru dị ka mkpụmkpụ mmepụta okirikiri, elu mkpụrụ, na elu ịdị ọcha. Otú ọ dị. ,ọ na-achọ njikarịcha nke ọnọdụ gbaa ụka na nyocha nke ụdị na-emepụta ihe dị elu iji melite nrụpụta mmepụta ma belata ọnụ ahịa.
Usoro njikọ kemịkalụ maka mmepụta nke Paclitaxel
Ngwakọta kemịkalụ bụ ụzọ ọzọ dị mkpa maka mmepụta nke Paclitaxel. Usoro a na-eji nkà na ụzụ na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta Paclitaxel site na ụzọ njikọ chemical. ọnụ ahịa dị elu, nke na-egbochi ngwa ya bara uru.
Ngwakọta nke mmịpụta eke na njikọ kemịkalụ na usoro mmepụta
Iji merie adịghị ike nke otu mmepụta ụzọ, ndị nchọpụta na-enyochakwa nchikota nke eke mmịpụta na chemical synthesis na mmepụta usoro.This usoro mbụ extracts precursor bekee nke Paclitaxel si Taxus umu na-eji mgbaze mmịpụta, na mgbe ahụ na-atụgharị ha n'ime Paclitaxel iji chemical synthesis. technology.This usoro jikọtara uru nke eke mmịpụta na chemical njikọ, na-eme ka mmepụta arụmọrụ na ịdị ọcha, na-ebelata mmepụta ihe.
III.Ihe ịma aka na ntụzịaka nkwalite na teknụzụ mmepụta Paclitaxel
Imeziwanye arụmọrụ mmịpụta na ịdị ọcha: ịzụlite ụzọ na teknụzụ mmịpụta nke ọma na gburugburu ebe obibi, dị ka ihe mgbaze ọhụrụ, enzymes mejupụtara, wdg, iji melite arụmọrụ mmịpụta na ịdị ọcha nke Paclitaxel.
Na-eme ka ọnọdụ gbaa ụka na nyocha ụdị dị elu na-amịpụta: Na-ebuli ọnọdụ gbaa ụka (dị ka ihe mejupụtara ọkara, okpomọkụ, uru pH, wdg) na nyochaa ụdị dị elu na-enye aka iji mụbaa mkpụrụ na ịdị ọcha nke mmepụta Paclitaxel dabere na gbaa ụka.
Mbelata mmepụta ihe: Ịmepụta akụrụngwa ọhụrụ, imeziwanye usoro mmepụta ihe, yana nweta nnukwu mmepụta iji belata ọnụ ahịa mmepụta nke Paclitaxel ma melite asọmpi ahịa ya.
Ijikwa njikwa mma na-ewusi ike: Ịmepụta usoro njikwa njikwa zuru oke iji jikwaa ịdị mma nke akụrụngwa, usoro mmepụta na ngwaahịa site na njikwa ogo siri ike na nnwale nyocha iji hụ na ịdịmma ngwaahịa na nchekwa.
Ịmepụta usoro ọhụrụ: Ịmepụta usoro ọhụrụ (dị ka nanomaterials, usoro liposome, wdg) iji melite bioavailability na nrụpụta ọrụ nke Paclitaxel na vivo dabere na adịghị ike ngwa ụlọ ọgwụ ya.
Na-agbasawanye mpaghara ngwa: na-agbasawanye mpaghara ngwa nke Paclitaxel gafere ọgwụgwọ ọrịa kansa (dị ka mgbochi mkpali, mmetụta antioxidant), iji gosipụta mmetụta ọgwụ ya sara mbara yana uru ngwa.
IV.Mkpebi na atụmanya
Site na ọganihu sayensị na teknụzụ na-aga n'ihu na mmụba ụlọ ọgwụ na-achọwanyePaclitaxel API, Usoro mmepụta na nkà na ụzụ nke Paclitaxel API na-aga n'ihu na-emepe emepe. N'ọdịnihu, ndị nchọpụta ga-anọgide na-enyocha usoro mmepụta ọhụrụ na ụzọ nkà na ụzụ iji meziwanye mmepụta mmepụta nke Paclitaxel, belata ụgwọ ọrụ mmepụta ihe, gbasaa ubi ngwa ya, ma na-enye onyinye dị ukwuu. maka ahụike mmadụ.
Cheta na: Enwere ike ịrụ ọrụ na ngwa ndị a kpọtụrụ aha n'isiokwu a site na akwụkwọ ndị e bipụtara n'ihu ọha.
Oge nzipu: Dec-13-2023