Paclitaxel bụ diterpenoid ewepụtara site na Taxus genus Taxus, ndị ọkà mmụta sayensị achọpụtala na o nwere ọrụ antitumor siri ike na nyocha nyocha.Ugbu a,paclitaxela na-ejikarị agwọ ọrịa cancer ara, ọrịa cancer ovarian, ọrịa cancer akpa ume na-abụghị obere cell, ọrịa pancreatic cancer, esophageal cancer, gastric cancer, isi na olu akpụ, adụ anụ ahụ sarcoma na ndị ọzọ dị njọ etuto ahụ, na ọ bụ otu n'ime ndị kasị ugboro ugboro. ejiri ọgwụ chemotherapy mee ihe na ụlọ ọgwụ.Yabụ kedu ka paclitaxel si alụ ọgụ kansa?Ka anyị lee anya n'okpuru.
Kedu ka paclitaxel si alụ ọgụ cancer?A maara nke ọma na n'oge nkewa sel nkịtị, a na-ekewa cell ahụ ụzọ abụọ.Mgbe emechara chromosome ahụ, filament spindle na-adọta ya n'ọnọdụ mbụ ya n'akụkụ abụọ, na spindle chọrọ depolymerization nke microtubules dị ka cytoskeleton na-etolite, chromosomes nwere ike imezu mitosis site na ịkwaga na okporo osisi n'okpuru traction nke spindle na. eriri spindle, ya mere microtubules dị ezigbo mkpa na nkewa sel.
Na 1979, ọkà mmụta ọgwụ Horwitz chọpụtara napaclitaxelnwere ike ijikọ na tubulin ma kwalite polymerization nke tubulin ka ọ bụrụ microtubules, si otú ahụ na-egbochi nhazi physiological nkịtị nke microtubules, na-eme ka ọ ghara ịmepụta spindles na spindle filaments, na-eme ka mkpụrụ ndụ ghara ikewa nkewa na-egbochi mmepụta ngwa ngwa nke mkpụrụ ndụ cancer ma na-ebute apoptosis. nke mkpụrụ ndụ cancer.Ya mere, n'etiti ọgwụ mgbochi ọrịa cancer, a na-ewere paclitaxel dị ka microtubule inhibitor na mitosis.
Cheta na: Enwere ike ịrụ ọrụ na ngwa a kọwara n'isiokwu a site na akwụkwọ ndị e bipụtara.
Ọgụgụ agbatịkwuru:Yunnan Hande Biotechnology Co., Ltd nọ na-elekwasị anya na mmepụta nke paclitaxel kemgbe afọ 28.Ọ bụ ụlọ ọrụ izizi nọọrọ onwe ya n'ụwa nke paclitaxel ọgwụ anticancer sitere na osisi nke US FDA, European EDQM, Australian TGA, China CFDA, India, Japan na ụlọ ọrụ nchịkwa mba ndị ọzọ kwadoro.ụlọ ọrụ.Ọ bụrụ na ị chọrọ ịzụPaclitaxel API,biko kpọtụrụ anyị online.
Oge nzipu: Sep-30-2022