Taxus chinensis (Yew), ụdị osisi oge ochie hapụrụ mgbe Quaternary glacier gasịrị, edepụtara dị ka osisi dị ụkọ n'ụwa na nke dị ize ndụ na ụdị iri kachasị egwu n'ụwa. "Panda nnukwu osisi".
Yabụ,
Dị ka a"fossil osisi", kedu ihe mmetụta na ngwa nke yew wepụ?
Yew, bụ osisi Taxus nke Taxaceae. E nwere ụdị yew 11 n'ụwa, na-ekesa na okpomọkụ na mpaghara okpomọkụ nke ugwu ugwu. E nwere ụdị 4 na 1 dị iche iche na China, ya bụ, Chinese yew, ugwu ọwụwa anyanwụ yew, Yunnan yew. ,South yew na Tibet yew, nke a na-ekesa na Northeast, South China na Southwest China.Paclitaxel amịpụtara site n'ụgbụgbọ na epupụta nke yew nwere pụtara curative mmetụta on a dịgasị iche iche nke elu ọrịa cancer na a maara dị ka" ikpeazụ akara agbachitere maka ọgwụgwọ ọrịa cancer."
Akụkọ mmepe nke paclitaxel:
Na 1963, American chemists MCWani na Monre E.wall bu ụzọ kewapụrụ crude wepụ nke paclitaxel site n'ụgbụgbọ na osisi nke Pacific yew, nke na-eto n'ime ọhịa nke ọdịda anyanwụ United States. na crude wepụ nke paclitaxel nwere nnukwu ọrụ na mouse tumor cell in vitro, wee malite ikewapụ akụkụ a na-arụ ọrụ. N'ihi ọdịnaya dị oke ala nke ihe na-arụ ọrụ na osisi, ọ bụ na 1971 ka ha na Andre t.McPhail kwadoro. , onye prọfesọ kemịkalụ na Mahadum Duke iji chọpụta usoro kemịkalụ nke ihe na-arụ ọrụ - tetracyclic diterpene compound, wee kpọọ ya taxol.
Kedu ihe bụ paclitaxel?
Paclitaxel bụ monomer diterpenoid amịpụtara na ogbugbo nke Natural Plant Taxus.Ọ bụ mgbagwoju nke abụọ metabolite.Ọ bụkwa nanị ọgwụ a maara iji kwalite microtubule polymerization na stabilize polymerized microtubules.Isotope tracing gosiri na paclitaxel bụ nanị ejikọta ya na polymerized microtubules na mere. adịghị emeghachi omume na unpolymerized tubulin dimers. Mgbe ịkpọtụrụ paclitaxel, mkpụrụ ndụ ga-akwakọba ọnụ ọgụgụ dị ukwuu nke microtubules n'ime sel. Nchịkọta nke microtubules ndị a na-egbochi ọrụ dị iche iche nke mkpụrụ ndụ, karịsịa na-akwụsị nkewa sel na mitotic ogbo ma na-egbochi nkewa sel nkịtị.
Ngwa nke paclitaxel:
1.Anticancer
Paclitaxel bụ ọgwụ mbụ maka ọrịa cancer ovarian na ọrịa ara ara dị elu. Ụlọ ọrụ nlekọta ọrịa cancer nke mba malitere ule ụlọ ọgwụ mmadụ na mmalite dị ka 1983 iji nwalee nsí ya na mgbochi ọrịa cancer.
A na-ejikarị Paclitaxel eme ihe na ọrịa cancer ovarian na ọrịa ara ara site na nyocha nke abụọ na nke atọ. Ọ nwekwara mmetụta ụfọdụ na ọrịa cancer akpa ume, cancer colorectal, melanoma, isi na olu cancer, lymphoma na ụbụrụ ụbụrụ.
2.Antitumor
Paclitaxel bụ nhọrọ mbụ nke ọgwụ mgbochi tumor na ụlọ ọgwụ n'ụwa nile. Ọ nwere ike ịkwalite mgbakọ nke microtubules site n'ịkwalite polymerization nke spindle tubulin subunits.Ọ bụ ọgwụ mgbochi microtubule antitumor.
3. Ọgwụgwọ ọrịa ogbu na nkwonkwo
Nnyocha egosiwo na FDA kwadoro taxol maka ọrịa ogbu na nkwonkwo, na paclitaxel gel bụ nkwadebe maka paclitaxel na ọrịa ogbu na nkwonkwo.
Oge nzipu: Eprel-21-2022