Paclitaxel (Paclitaxel) bụ ọgwụ na-egbochi ọrịa kansa eke sitere na osisi yew, nke nwere usoro kemịkalụ pụrụ iche na mmetụta ọgwụ.Kemgbe achọpụtara paclitaxel na 1971, ngwa ụlọ ọgwụ ya enwetala nsonaazụ dị ịrịba ama.N'akwụkwọ a, chemical Ọdịdị na pharmacological edinam nkepaclitaxela ga-atụle.
Usoro kemịkalụ nke paclitaxel
Usoro kemịkalụ nke paclitaxel dị mgbagwoju anya, nke nwere ọtụtụ ihe mgbanaka, gụnyere isi ihe diterpenoid, nke bụ akụkụ bụ isi nke mmetụta mgbochi ọrịa cancer nke paclitaxel.Mkpụrụ ndụ Paclitaxel nwekwara ọtụtụ hydroxyl na ketone dị iche iche, na ọnọdụ na ọnụ ọgụgụ nke otu ndị a na-ekpebi ọrụ ọgwụ pụrụ iche.
Mmetụta ọgwụ ọgwụ nke paclitaxel
1. Microtubule stabilization: Paclitaxel nwere ike ịkwalite polymerization nke microtubules ma mee ka microtubules polymerized, nke bụ isi usoro nke mmetụta anticancer ya.Microtubules na-arụ ọrụ dị mkpa na nkewa sel, na paclitaxel na-egbochi uto tumor site na ịkwado microtubules na igbochi nkewa sel.
2, mee ka njide okirikiri cell: paclitaxel nwekwara ike ime ka ejidere cell cell, ka mkpụrụ ndụ ghara ịga n'ihu na-ekewa ma gbasaa.Nke a bụ usoro ọzọ dị mkpa nke mmetụta anticancer ya.
3, kpalite apoptosis: paclitaxel nwere ike ime ka nkwupụta nke ọtụtụ ndị mgbasa ozi pro-apoptosis, mee ka usoro apoptosis nke mkpụrụ ndụ cancer dịkwuo ngwa.
4, iwu nke ndị mgbasa ozi mgbochi apoptotic: paclitaxel nwekwara ike ịhazi ọrụ nke ndị mgbasa ozi na-eme ihe iji dozie usoro apoptosis na mmụba.
Mmechi
Paclitaxel bụ ụdị ọgwụ anticancer sitere n'okike nwere usoro kemịkalụ pụrụ iche na omume ọgwụ.Ọ nwere ike igbochi uto tumor nke ọma site n'ịkwalite microtubule polymerization, na-eme ka microtubules polymerized guzosie ike, na-ebute njide okirikiri cell na ịkpata apoptosis cell.Otú ọ dị, nsi na mmetụta dị n'akụkụ nke paclitaxel bụkwa nchegbu na ngwa ụlọ ọgwụ.Nnyocha ndị ọzọ na nghọta nke mmetụta ọgwụ ọgwụ nke paclitaxel ga-enyere aka ịkwalite ojiji nke ụlọ ọgwụ, meziwanye ọgwụgwọ ọgwụgwọ, ma belata mmetụta.
Outlook n'ọdịnihu
Ọ bụ ezie na ngwa ụlọ ọgwụ nke paclitaxel arụpụtala ihe dị ịrịba ama, nsogbu nke oke ego ya na ụkọ nri ka dị.Ya mere, ndị ọkà mmụta sayensị na ngalaba nke ihe ndị na-emepụta ihe na nkà mmụta ọgwụ na-arụ ọrụ ịchọta ụzọ ọzọ na paclitaxel iji dozie nsogbu ọkọnọ ya ma belata ụgwọ ọrụ mmepụta ihe.Ke adianade do, nnyocha n'ime pharmacological mmetụta nkepaclitaxelga-enye aka n'ịchọpụta usoro ọgwụgwọ dị irè karị iji lụso ụdị ọrịa kansa dị iche iche ọgụ.
N'ime ọmụmụ ihe na-aga n'ihu na ule ụlọ ọgwụ, nchikota nke paclitaxel na ọgwụ ndị ọzọ na-ahụ maka ọrịa cancer egosiwo atụmanya dị mma.Site na ijikọta paclitaxel na ọgwụ ndị ọzọ, enwere ike ịkwalite ịdị irè nke ọgwụgwọ yana mpụta nke nguzogide belata.N'ọdịnihu, na mgbasawanye nke ọgwụ ziri ezi na echiche ọgwụgwọ ahaziri onwe ya, nyocha na nghọta nke mmetụta ọgwụ nke paclitaxel ga-adị omimi karị, a ga-ewepụtakwa usoro ọgwụgwọ ziri ezi ma dị irè maka ndị ọrịa cancer.
N'izugbe, paclitaxel bụ ọgwụ na-egbochi ọrịa kansa eke nwere usoro kemịkalụ pụrụ iche na mmetụta ọgwụ.Site na ọganihu na-aga n'ihu nke sayensị na nkà na ụzụ na nyocha miri emi, anyị na-atụ anyapaclitaxelna-ekere òkè dị ukwuu n'ịgwọ ọrịa cancer dị iche iche n'ọdịnihu, na-ebute ọgwụgwọ ọgwụgwọ dị mma na ndụ ndụ ndị ọrịa.
Rịba ama: A na-enweta uru na ngwa ndị nwere ike ime n'isiokwu a site na akwụkwọ ndị e bipụtara.
Oge nzipu: Nov-15-2023