N'ime oke nrụgide a dị elu, ụda dị elu na gburugburu ebe obibi accelerated eruba, ụfọdụ ndị na-egbu oge ụra n'abalị, nke na-eme ka ọ na-esiri ike ihi ụra, na-akpata ụfọdụ nsogbu ihi ụra. Gịnị ka anyị kwesịrị ime? Ọ bụrụ na enwere nsogbu, a ga-enwe nsogbu. bụrụ ụzọ isi dozie nsogbu ahụ.
N'oge a ọtụtụ mmadụ na-anụmelatoninHa na-eche na melatonin bụ ihe mara mma ngwaahịa. N'ezie, melatonin bụ ihe esịtidem hormone na-akpali eke ụra.It imeri ihe mgbochi ụra na mma na-ehi ụra àgwà site regulating ndị mmadụ eke sleep.N'ahịa, ọ bụ ihe na-esiwanye ewu ewu na-elekọta ahụike ngwaahịa ka. nyere aka ihi ụra.
Dị ka ọnụ ọgụgụ nke World Health Organisation si kwuo, ọnụ ọgụgụ nsogbu ihi ụra zuru ụwa ọnụ bụ 27%, nke ghọrọ nsogbu uche nke abụọ na-emekarị n'ụwa. Ihe fọrọ nke nta ka ọ bụrụ otu onye n'ime mmadụ atọ nwere nsogbu ihi ụra na otu onye n'ime 10 na-ezute usoro nchọpụta nyocha maka. Insomnia.Akụkọ nke otu ụlọ ọrụ nyocha ụra nke China wepụtara na-egosi na ihe karịrị nde mmadụ 300 na China nwere nsogbu ihi ụra, ebe ogo nke ehighị ụra nke ọma na ndị okenye ruru 38.2%.
Ya mere, Melatonin nwere ike inye aka ihi ụra? Olee mmetụta ọ na-enwe?
###Ka anyị leba anya na melatonin na ọrụ ya.
Melatonin (MT) bụ otu n'ime homonụ zoro ezo site na pineal gland.Melatonin bụ nke indole heterocyclic ogige.Ya chemical aha bụ N-acetyl-5 methoxytryptamine, nke a makwaara dị ka pinealoxin.Mgbe melatonin synthesis, ọ na-echekwara na pineal gland. Mmetụta ọmịiko na-eme ka mkpụrụ ndụ pineal gland hapụ melatonin. Ihe nzuzo nke melatonin nwere ụda circadian doro anya, nke a na-egbochi ya n'ehihie ma na-arụ ọrụ n'abalị.
Melatonin nwere ike igbochi hypothalamic pituitary gonadal axis, belata ọdịnaya nke gonadotropin na-ewepụta homonụ,gonadotropin, luteinizing hormone na estrogen follicular, ma mee ihe ozugbo na gonads iji belata ọdịnaya nke androgen, estrogen na progesterone. Ọ na-achịkwa ọrụ nke gland endocrine dị iche iche n'ime ahụ, si otú a na-achịkwa ọrụ nke ahụ anyị dum n'ụzọ na-edoghị anya.
Ọrụ na iwu nke Melatonin
1) Gbanwee rhythm circadian
Melatonin secretion nwere a circadian rhythm.Mgbakwunye melatonin si n'èzí ahụ nwere ike ịnọgide na-enwe melatonin larịị n'ime ahụ na a na-eto eto na steeti, gbanwee ma weghachi circadian rhythm, ọ bụghị nanị na-amụba ụra na mma ụra mma, kamakwa mma na-arụ ọrụ ọnọdụ nke ahụ dum, na-eme ka ndụ dịkwuo mma ma na-egbu oge usoro ịka nká. N'ihi na ọganihu nke afọ, pineal gland na-ebelata ruo mgbe calcification, na-eme ka ike gwụ ma ọ bụ na-apụ n'anya nke ụda nke elekere ndụ. Karịsịa mgbe afọ 35 gasịrị, melatonin zoro ezo nke ahụ na-ebelata nke ukwuu, na nkezi mbelata nke 10 ~ 15% kwa afọ 10, na-akpata nsogbu ụra na ọtụtụ nsogbu ọrụ. Mbelata ọkwa melatonin na ọnwụ ụra bụ otu n'ime ihe ịrịba ama dị mkpa nke ụbụrụ mmadụ. ịka nká.
2) Egbula oge ịka nká
The pineal gland nke ndị agadi na-eji nwayọọ nwayọọ na-ebelata, na nzuzo nke MT na-ebelata otú ahụ. Ọnụ ọgụgụ nke Mel chọrọ akụkụ dị iche iche n'ime ahụ ezughi oke, na-akpata ịka nká na ọrịa. Ndị ọkà mmụta sayensị na-akpọ pineal gland oge ịka nká nke ahụ. MT si n'èzí, anyị nwere ike tụgharịa elekere ịka nká.
3) Gbochie ọnya
N'ihi na MT nwere ike ịbanye n'ime mkpụrụ ndụ n'ụzọ dị mfe, enwere ike iji ya chebe DNA nuklia. Ọ bụrụ na DNA mebiri emebi, ọ nwere ike ibute ọrịa kansa. Ọ bụrụ na Mel zuru ezu n'ọbara, ọ dịghị mfe ịnweta kansa.
4) Regulatory mmetụta na Central ụjọ usoro
Ọnụ ọgụgụ dị ukwuu nke ụlọ ọgwụ na nnwale ọmụmụ na-egosi na melatonin, dị ka endogenous neuroendocrine hormone, nwere kpọmkwem na-apụtaghị ìhè physiological ụkpụrụ na Central ụjọ usoro, ọgwụgwọ mmetụta na ụra nsogbu, ịda mbà n'obi na uche ọrịa, na-echebe mmetụta na akwara mkpụrụ ndụ. ,melatonin nwere mmetụta na-akụda mmụọ, nwekwara ike ịgwọ ịda mbà n'obi na psychosis, nwere ike ichebe irighiri akwara, nwere ike ibelata ihe mgbu, na-achịkwa hormones nke hypothalamus wepụtara na ihe ndị ọzọ.
5) Iwu nke usoro ahụ ji alụso ọrịa ọgụ
N'ime afọ iri na-adịbeghị anya, mmetụta nchịkwa nke melatonin na usoro ahụ ji alụso ọrịa ọgụ adọtala ndị mmadụ nlebara anya. Nnyocha e mere n'ụlọ na ná mba ọzọ egosila na melatonin abụghị nanị na-emetụta uto na mmepe nke akụkụ ahụ ndị na-alụso ọrịa ọgụ, kamakwa ọ na-achịkwa mgbochi humoral, mgbochi cell na cytokines. Dịka ọmụmaatụ, melatonin nwere ike ịhazi ihe mgbochi cellular na nke ọchị, yana ọrụ nke cytokines dị iche iche.
6) Regulatory mmetụta na obi usoro
Ọrụ nke sistemu vaskụla nwere usoro mgbaka okirikiri doro anya na ụda oge nke oge, gụnyere ọbara mgbali elu, ọnụọgụ obi, mmepụta obi, renin angiotensin aldosterone, wdg. Ọkwa serum melatonin secretion nwere ike igosipụta oge kwekọrọ n'ụbọchị na oge kwekọrọ n'afọ. .Na mgbakwunye, nsonaazụ nnwale ndị dị mkpa gosipụtara na mmụba nke nzuzo MT n'abalị na-ejikọta ya na mbelata nke ọrụ obi; mezie mmeghachi omume nke akwara dị n'akụkụ na norepinephrine.
7) Tụkwasị na nke ahụ, melatonin na-achịkwa usoro iku ume mmadụ, usoro nri nri na usoro urinary.
Aro maka Melatonin
melatoninọ bụghị ọgwụ.Ọ nwere ike ịrụ ọrụ inyeaka na ehighi ura ma ọ nweghị mmetụta ọgwụgwọ. Maka nsogbu ndị dị ka ụra adịghị mma ma na-eteta n'ọkara, ọ gaghị enwe mmetụta dị mma nke ọma. N'ọnọdụ ndị a, ị ga-achọ ọgwụgwọ ahụike. n'oge ma nweta ọgwụgwọ ọgwụ ziri ezi.
Chọrọ ịmatakwu banyere melatonin?Hande agba mbọ na-enye ndị ahịa na mma na mma mmịpụta ngwaahịa.We nye elu-edu na elu-ọkọlọtọ melatonin ngwaahịa na-enyere gị aka n'ụzọ dị irè na-enyere gị aka imeziwanye ụra gị na-ebi ndụ rụọ ọrụ nke ọma kwa ụbọchị!
Oge nzipu: Mee-11-2022