Paclitaxel bụ ọgwụ dị mkpa a na-ejikarị agwọ ọrịa kansa, mana isi mmalite ya nwere oke.Iji gboo mkpa maka paclitaxel n'ahịa ọgwụ, ndị ọkà mmụta sayensị emeela nyocha buru ibu, yana ụzọ ọkara sịntetik na-aghọ ụzọ dị mkpa nke mmepụta.Edemede a ga-ewebata usoro nke paclitaxel nke ọkara-synthesizing sitere na 10-deacetylbaccatin III (10-DAB) ma mesie mkpa ọ dị na ngalaba nke njikọ ọgwụ.
Paclitaxel, bụ́ nke dịpụrụ adịpụ na mbụ n'ụgbụgbọ osisi yew Pacific, bụ ihe a ma ama maka ihe pụrụ iche ọ na-egbochi ọrịa cancer.Agbanyeghị, yew Pacific bụ akụrụngwa sitere n'okike nwere oke, ezughi oke iji gboo mkpa ahụike ọgbara ọhụrụ maka paclitaxel.Mmepe nke ụzọ ọkara synthetic emewo ka nnukwu mmepụta nke paclitaxel nwee ike, na 10-deacetylbaccatin III bụ ihe dị oke egwu n'etiti.
Nkwadebe nke 10-DAB na Semi-Synthetic Paclitaxel:
10-DAB bụ etiti dị oke mkpa na ụzọ ọkara synthetic na paclitaxel ma chọọ ọtụtụ usoro maka nkwadebe ya.Dịka, njikọ nke 10-DAB na-amalite site na mmalite nke paclitaxel, taxuyunnanine C, nke sitere na baccatin III.Akwụsịla Baccatin III na mbụ iji mepụta 10-deacetylbaccatin III.Na-esote, 10-deacetylbaccatin III na-enweta ọtụtụ mmeghachi omume, gụnyere hydrogenation, nnọchi, epoxidation, hydrolysis, na ndị ọzọ, n'ikpeazụ na-agbanwe ghọọ 10-DAB.
Ngwa nke 10-DAB na Semi-Synthetic Paclitaxel:
Njikọ nke 10-DAB emeghewo ụzọ ọhụrụ maka ọkara njikọ nke paclitaxel, na-enye nkwado na mmepụta ọgwụ.Paclitaxel bụ ọgwụ mgbochi ọrịa cancer nke sara mbara nke a na-eji na-agwọ ụdị ọrịa cancer dị iche iche, gụnyere ovarian, ara, na cancer akpa ume.Ụzọ semi-synthetic ụzọ na-ebelata ọnụ ahịa mmepụta ọgwụ, na-eme ka nhọrọ ọgwụgwọ a dị mkpa dịkwuo mfe maka ndị ọrịa.
Mmechi:
Usoro nke ọkara-synthesizing paclitaxel sitere na 10-DAB enwetawo ihe ịga nke ọma dị ukwuu n'ọhịa nke njikọ ọgwụ.Ọ bụghị naanị na ọ na-eleba anya n'okwu gbasara isi mmalite okike maka paclitaxel kamakwa ọ na-akwalite nrụpụta mmepụta na nkwado.Nkà na ụzụ a na-anọchi anya ihe dị ịrịba ama na mmepụta ọgwụ mgbochi ọrịa cancer ma na-ekwe nkwa maka ọganihu n'ihu na ngalaba ahụike iji lụso ọrịa siri ike dị ka ọrịa cancer ọgụ.N'ọdịnihu, ndị na-eme nchọpụta ga-anọgide na-emeziwanye ụzọ nchịkọta iji meziwanye arụmọrụ ma belata ụgwọ ọrụ, n'ikpeazụ na-erite uru n'ọtụtụ ndị ọrịa.
Rịba ama: Uru nwere ike na ngwa ndị a kpọtụrụ aha n'isiokwu a dabere na akwụkwọ ọha dị na ya.
Ọgụgụ ọzọ: Yunnan Hande Biotech Co., Ltd., nke nwere afọ 26 lekwasịrị anya na mmepụta paclitaxel, bụ onye nrụpụta nnwere onwe zuru ụwa ọnụ nke ihe ọkụkụ na-ewepụta ọgwụ mgbochi ọrịa cancer paclitaxel na-arụ ọrụ ọgwụ, nke ụlọ ọrụ nchịkwa dị ka US FDA, European EDQM kwadoro. , Australia TGA, China CFDA, India, Japan, na ndị ọzọ.Yunnan Hande Paclitaxel, dị na ngwaahịa, bụ ndị nrụpụta na-ere ya ozugbo.Biko nweere onwe gị ịkpọ maka ajụjụ na +86 18187887160 (WhatsApp).
Oge nzipu: Ọktoba 24-2023