Natural paclitaxel: ọgwụ na-egbu egbu na-egbu egbu nke ukwuu

Paclitaxel, ọgwụ anticancer sitere n'okike nke nwere usoro C47H51NO14, ejirila ya mee ihe n'ọtụtụ ebe n'ịgwọ ọrịa kansa ara, ọrịa cancer ovarian na ụfọdụ ọrịa kansa, olu na ngụgụ.Diterpenoid alkaloid nwere ọrụ anticancer,paclitaxelNdị na-ahụ maka ihe ọkụkụ, ndị na-ahụ maka kemist, ndị na-ahụ maka ọgwụ na ndị na-ahụ maka ihe ndị dị ndụ molecular kwadoro nke ukwuu n'ihi akwụkwọ akụkọ ya na usoro kemịkalụ dị mgbagwoju anya ya, ọrụ ndụ dị ukwuu na nke dị ịrịba ama, usoro omume ọhụrụ na nke pụrụ iche, yana ụkọ akụrụngwa sitere n'okike, na-eme ka ọ bụrụ kpakpando na nyocha nyocha nke anticancer. ọkara nke abụọ nke narị afọ nke 20.

Usoro ọrụ nke paclitaxel

Paclitaxel na-egbochi mgbasa nke mkpụrụ ndụ kansa site n'ịkwalite njide okirikiri cell na ịkpata ọdachi mitotic.Ọdịdị kemịkalụ ya dị mgbagwoju anya na-enye ya usoro ihe omume pụrụ iche nke ndu.Paclitaxelnwere ike igbochi mgbasawanye cell site na igbochi polymerization nke tubulin na ibibi netwọk microtubule cell.Na mgbakwunye, paclitaxel nwekwara ike ime ka nkwupụta nke ndị mgbasa ozi pro-apoptotic na-achịkwa ọrụ nke ndị mgbasa ozi mgbochi apoptotic, si otú ahụ na-ebute apoptosis nke mkpụrụ ndụ cancer.

Ọrụ mgbochi ọrịa cancer nke paclitaxel

Paclitaxel adọtala nlebara anya nke ukwuu n'ihi oke arụmọrụ ya na obere nsi nke ọrụ anticancer.Na omume ụlọ ọgwụ, egosila paclitaxel nwere mmetụta ọgwụgwọ dị ịrịba ama na ọrịa cancer dị iche iche, gụnyere ọrịa ara ara, ọrịa cancer ovarian, ụfọdụ ọrịa isi na olu, na ọrịa cancer akpa ume.Site na usoro ndu ya pụrụ iche, paclitaxel nwere ike igbochi mgbasa nke mkpụrụ ndụ kansa n'ụzọ dị irè ma kpalite apoptosis nke mkpụrụ ndụ kansa.Tụkwasị na nke ahụ, ọrụ mgbochi ọrịa cancer nke paclitaxel na-ejikọta ya na ikike ya ịchịkwa nzaghachi mgbochi nke mkpụrụ ndụ tumo.

Ụkọ akụrụngwa nke paclitaxel

Ọ bụ ezie na paclitaxel nwere nnukwu ọrụ anticancer, ụkọ akụrụngwa ya egbochila iji ya eme ihe n'ụlọ ọgwụ.A na-ewepụtakarị Paclitaxel site na osisi yew nke Pacific, na n'ihi oke ihe ndị sitere n'okike, mmepụta nke paclitaxel adịte aka na-egbo mkpa ụlọ ọgwụ.Ya mere, ịchọ ebe ọhụrụ nke paclitaxel, dị ka mmepụta nke paclitaxel site na biosynthesis ma ọ bụ chemical synthesis, bụ ihe na-elekwasị anya na nyocha ugbu a.

mmechi

Dị ka ọgwụ mgbochi ọrịa cancer eke,paclitaxelnwere njiri mara oke arụmọrụ, obere toxicity na ụdịdị dị iche iche, yana usoro ndu ya pụrụ iche nke omume yana ọrụ anticancer dị ịrịba ama na-eme ka ọ bụrụ ọgwụ ọgwụgwọ ọrịa cancer dị mkpa na omume ụlọ ọgwụ.Otú ọ dị, n'ihi ụkọ nke ihe onwunwe ya, ngwa ya sara mbara na omume ụlọ ọgwụ dị oke.Ya mere, nyocha n'ọdịnihu kwesịrị ilekwasị anya n'ịchọta isi mmalite nke paclitaxel iji gboo mkpa ụlọ ọgwụ ma nyekwuo nhọrọ ọgwụgwọ maka ndị ọrịa cancer.

Rịba ama: A na-enweta uru na ngwa ndị nwere ike ime n'isiokwu a site na akwụkwọ ndị e bipụtara.